Comix zone

Comix zone was released for Sega Genesis in 1995.

The game features a unique 'comic book' style screen progression, as your character fights his way from one frame of the comic to another. You can get knifes and explosives to help you along your way along with energy top-ups.

Original description:

ENTER THE COMIX ZONE: THE FIRST TRULY INTERACTIVE COMIC BOOK!

Play as Sketch Turner, a street-wise comic book artist who gets trapped in the comic book world of his own creation.
Warp into the Comix Zone with all the action and adventure of your favorite comics!
Battle panel by panel through full comic book pages drawn by real comic book artists!
Sharpen your fighting skills to defeat mutant enemies drawn in by Mortus, public enemy no. 1.
Rip up the page with superhero power-ups and tons of intense fighting moves!

Instructions

Enter - start;    Arrows - move;    X - jump;    C - block;    Z - attack;
A S D - items;    Esc = exit fullscreen;

You can change keyboard settings, save (F5) and load (F8) the game.
Put your mouse over the game and choose your settings, you can also play the game in fullscreen.