Dr. Mario

Dr. Mario is a 1990 Mario puzzle game. Nintendo developed and published the game for NES and Game Boy consoles. Dr. Mario received positive reception, appearing on several "Best Nintendo Games of All Time" lists. The game has been ported, remade, or has had a sequel on every Nintendo home console since the NES as well as most portable consoles.

Original description:

Dr. Mario - the prescription is fun.

It's Dr. Mario for an intense new challenge! Mario throws multi-colored vitamin capsules into a bottle that contains an ugly variety of nasty viruses. You can move, shift or spin capsules as they fall. Arrange them to align with other capsules on top of the virus. If you can get four or more of the same color in a row, POOF! They disappear! Destroy all of the viruses in the bottle and you progress to the next round where things get even more difficult!

Instructions

Enter - start (pause);    Arrows - move;    Z or X - rotate;    Esc = exit fullscreen;

You can change keyboard settings, save (F5) and load (F8) the game.
Put your mouse over the game and choose your settings, you can also play the game in fullscreen.