Mike Tyson's Punch-Out!!

Before the release of Mike Tyson's Punch-Out!! in North America, Nintendo released the game in a Famicom cartridge titled Punch-Out!! in Japan, without Mike Tyson in it. The final opponent in this version was Super Macho Man, who was also the final opponent in the Super Punch-Out!! arcade game. When Mike Tyson's Punch-Out!! sold well in North America, Nintendo later released the Mike Tyson version in Japan.

Original description:

Meet the ultimate challenge Fight Mike Tyson!

It's a right jab, a left hook, an uppercut - it's Mike Tyson's Punch-Out!! where you'll get the chance to compete against boxers from around the globe. Punch your way through 13 bouts in the minor, major and world circuits against tough contestants like Piston Honda, Glass Joe, Super Macho Man and many, many more! Defeat all your opponents and meet the ultimate challenge against the World Heavyweight Champion Mike Tyson in the greatest fight of all - The Dream Bout! Knockout Tyson and you can become WVBA (World Video Boxing Association) Champ!

Instructions

Enter - start;    Z - right hand;    X - left hand;
UP + Z or X = hit enemy in the head;    DOWN - block;
RIGHT or LEFT - dodge in the direction ;    2 x DOWN = duck;
Space - pressed in between rounds, it will regain some of your energy;

You can change keyboard settings, save (F5) and load (F8) the game.
Put your mouse over the game and choose your settings, you can also play the game in fullscreen.